Recombinant secretory IgA for immune intervention against mucosal pathogens.
نویسنده
چکیده
Mucosal epithelia of the human body, including the lining of the digestive, respiratory and urogenital tracts, comprises a vast surface permanently exposed to attack by exogenous pathogens. Protection of mucosal surfaces against colonization and possible invasion by pathogenic microorganisms is provided by a combination of constitutive non-specific substances such as mucus, lysozyme, lactoferrin and lactoperoxidase, and also by a specific mechanism that relies on a special class of antibodies known as sIgA [l-31. These antibodies are believed to operate by agglutinating potential invaders and facilitating their clearance by peristaltic or mucociliary movements. The delivery of micro-organisms and macromolecules to the mucosa-associated lymphoid tissue (MALT) is performed at the sampling site by a specialized type of highly invaginated enterocyte, the M-cell [4,5]. M-cells ingest pathogens by phagocytosis, pass them to underlying antigen-presenting cells, which after antigen processing, activate T-cells residing in the MALT. T-helper cells, in turn, stimulate B-cells to proliferate and differentiate into IgAproducing plasma cells. Some activated Tand B-cells remain in the sampling site area and continue to produce IgA locally, whereas others spread immune protection throughout the body by entering the circulation and migrating to distant mucosal and glandular effector sites (Figure
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عنوان ژورنال:
- Biochemical Society transactions
دوره 25 2 شماره
صفحات -
تاریخ انتشار 1997